Oregon vs. Michigan predictions, picks, and best bets for Saturday

Week 10 of college football’s schedule promises to be an exciting one. However, when the top-seeded Oregon Ducks go to play the defending national champion Michigan Wolverines, all eyes should be on Ann Arbor.

The Ducks are two-score favorites before kickoff, with an over/under of 44.5, despite this intriguing angle. Let’s go into our professional predictions and picks for this Big Ten matchup between Michigan and Oregon.

Oregon vs. Michigan predictions and best bets



  • Oregon -14.5:


    -108 at DraftKings



  • 1st Quarter – Oregon Total Points Over 6.5:


    -166 at DraftKings



  • 3rd Quarter Spread – Michigan +3.5:


    -116 at FanDuel

At home, it’s difficult to wager against a team like Michigan to lose by more than two touchdowns, but the Oregon Ducks are superior in many ways.

Oregon is not in danger from Michigan’s passing style. As a result, this game is highly comparable to Oregon’s previous Big Ten contests: the Ducks have halted the run, and everything else has fallen into place. The Ducks should be able to manage this spread, despite its size.

Oregon’s ability to score early has been a major factor in their success this season. The only time the Ducks have fallen below this 6.5-point line this season was when they missed a two-point conversion against Ohio State. The Ducks have scored a touchdown in the first quarter of every game this season.

Oregon, on the other hand, is a touch slow at first. When the third-quarter spread is 3.5 points, the Ducks are 2-6 ATS this season. According to those stats, Oregon has a history of third-quarter issues, so it makes sense to wager on the Wolverines to stay within a field goal during those 15 minutes.

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Oregon vs Michigan moneyline odds analysis

Why Oregon could win as the favorite

Caesars Sportsbook offers the best odds at -650.

Many questioned Oregon’s status as a top college football team early in the season. They had allayed any misgivings after a few weeks.

It’s evident that Dan Lanning has one of the best teams in the nation after victories over Illinois, Ohio State, and Boise State. For a team that has been recovering gracefully, traveling to Ann Arbor on Saturday appears to be just another challenge.

Jordan James, Tez Johnson, and Dillon Gabriel are one of the nation’s best offensive trios. Being able to dominate both on the ground and in the air is a significant advantage, and offensive coordinator Will Stein makes sure everything is set up just right.

Dan Lanning’s Georgia roots are showing on defense. In order to shut down the run game, the team is dominant in the trenches, and secondary players like Jabbar Muhammad frequently close throwing windows.

The disparity between these two teams is stark when they play Michigan, a squad that hasn’t even decided on a quarterback or found their rhythm.

Why Michigan could win as the underdog

The best odds at FanDuel Sportsbook are +520.

In college football, home-field advantage is a genuine thing, and The Big House is one of the best venues for it. The nation’s top-ranked team, Oregon, will enter this match determined to defeat the reigning champions. But occasionally that motivation leads to mistakes.

Michigan’s roster is talented enough to win important games. The defense is still among the best in the nation, and they have players with offensive skill. Under center, Davis Warren has to take care of his duties.

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He only needs to deliver; he doesn’t need to be a superstar or carry the team on his shoulders. As straightforward as that may seem, the program has suffered this season due to that incapacity at the position. The Wolverines will gain momentum if they can find easy plays early on to boost Warren’s confidence and keep the Ducks defense off-balance. It may be anyone’s game after that.

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