Lions vs. Cowboys predictions, odds, picks and best bets for NFL Week 6

When the Cowboys host the Lions on FOX’s America’s Game of the Week, two of the NFC’s best teams square off at AT&T Stadium.

After the referees failed to make a call that significantly affected the Lions’ defeat to Dallas the previous season, Detroit is seeking retribution. Given that Detroit is a field-goal favorite at the best sportsbooks for NFL betting, the oddsmakers believe the Lions will get even.

Lions vs. Cowboys predictions and best bets

Lions at BetMGM Sportsbook -3:-115

Over 12.5 rushing attempts by Jahmyr Gibbs:-105 at Sportsbook bet365

Dallas’ weekly schedule was probably thrown in a blender, while the Lions are well-rested following a Week 5 bye. A protracted lightning delay caused the Cowboys vs. Steelers Sunday Night Football game to end beyond 1 a.m. ET.

Given the long list of ailments in Big D, Dallas’ Week 6 bye cannot arrive soon enough.

CB DaRon Bland, LB Eric Kendricks, DE Micah Parsons, DE DeMarcus Lawrence, and receiver Brandin Cooks are all sidelined. CB Trevon Diggs’ condition is labeled as unclear, and Kendricks backup LB Nick Vigil is in doubt.

It’s bad news for the Lions’ potent offense that the majority of the injuries are to defensive players. Playmakers like WR Jameson Williams, WR Amon-Ra St. Brown, RB Jahmyr Gibbs, and RB David Montgomery help Detroit be effective both on the ground and in the air.

The Cowboys haven’t been able to stop the run, and I think Gibbs and Montgomery will have big games, thus the Lions will cover the spread.

In three consecutive games, Gibbs has failed to score in his rushing attempts, and I believe a fourth is imminent.

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Lions vs. Cowboys odds for NFL Week 6

During the week, the spread increased to Cowboys +3.5, but it was soon bet back down to +3. According to TeamRankings, Dallas is 2-3 and Detroit is 3-1 against the spread.

When betting on the over, you would anticipate that the Lions’ offense would be profitable, yet Detroit is 3-1 on unders.

Since 2015, the Cowboys have dominated the Lions, winning six straight games. Since its opening in 2009, Detroit has failed to win in Dallas’ in&T Stadium.

Lions vs. Cowboys moneyline odds analysis

Why the Lions could win as the favorite

The best odds at DraftKings Sportsbook are -166.

It was remarkable when the Cowboys defeated the Steelers in Pittsburgh. But now Dallas has to contend with an even more explosive Lions offense.

Williams has been quarterback Jared Goff’s favorite target, while Gibbs and Montgomery have both surpassed 270 rushing yards this season. Williams leads the Lions with 289 receiving yards and is a consistent threat on downfield catches.

The Cowboys’ rushing attack, which ranks second-to-last with 82 yards per game, is difficult to watch. Although the Lions have been vulnerable to the pass, knowing Dallas’ offensive strategy makes defense simpler.

In the NFL, quarterback Dak Prescott has the second-most pass attempts. Although he has performed admirably, a pass-heavy offense cannot be sustained on a weekly basis.

Why the Cowboys could win as the underdog

The best odds at FanDuel Sportsbook are +148.

Will the Cowboys’ rushing offense finally start to show some life in this game?

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The lone ball carrier with more than 100 yards is running back Rico Dowdle, and Dallas has never exceeded 110 rushing yards in a game. Detroit will give WR CeeDee Lamb a lot of attention, which will give WR Jalen Tolbert another opportunity to make an impression.

In Week 5, Tolbert caught seven catches for 82 yards and a score, his best performance of the season. Tolbert must continue to step up now that Cooks is out.

It’s difficult to stop the Lions’ offense, but the Cowboys need to figure out a way to accomplish it. It might be a blowout at Jerry World otherwise.

In a 42-29 victory over the Seahawks in Week 4, Detroit scored the most points of the season.

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